Selected Publications
M.-C. Kao*, G.-Y. Liu, T.-C. Chuang, Y.-S. Lin, J.-A. Wuu, S.-L. Law. The N-terminal 178-amino-acid domain only of the SV40 large T antigen acts as a transforming suppressor of the HER-2/neu oncogene. Oncogene. 1998; 16: 547-554.
M.-C. Kao*, S.-L. Law, T.-C. Chuang and Y.-S. Lin. In virto gene transfer in mammalian cells via a new cationic liposome formulation. Oncology reports. 1998; 5: 625-629.
S.-L. Law, M.-C. Kao, T.-C. Chuang. Formulation of transfection reagent of sphingosine and dioleoylphosphatidyl-ethanolamine. ROC Patent #114360, 2000.
T.-C. Chuang, Y. Yu, Y.-S. Lin, S.-S. Wang, M.-C. Kao*. The N-terminal domain of SV40 Large T antigen represses the HER2/neu-mediated transforming and metastatic potential in breast cancers. FEBS Lett. 2002; 511: 46-50.
T.-C. Chuang, T-D. Way, Y.-S. Lin, Y.-C. Lee, S.-L. Law, M.-C. Kao*. The Epstein-Barr virus nuclear antigen-1 may act as a transforming suppressor of the HER2/neu oncogene. FEBS Lett. 2002;532: 135-142.
T.-C. Chuang, Y.-C. Lee, G.-Y. Liu, Y.-S. Lin, J.-Y. Li, V. Wang, S.-L. Law, M.-C. Kao*. EBNA1 may prolong G2/M phase and sensitizes HER2/neu-overexpressing ovarian cells to both topoisomerase II-targeting and paclitaxel drugs. Biochem. Biophys. Res. Commun. 2003;307: 653-659.
J.-W. Li, T.-C. Chuang, A.-H. Yang, C.-K. Hsu, M.-C. Kao*. Clinicopathological relevance of HER2/neu and a related gene-protein cubic regression correlation in colorectal adenocarcinomas in Taiwan. Int. J. Oncol. 2005;26: 933-944.
V. Wang, T.-C. Chuang, Y.-D. Hsu, W.-Y. Chou, M.-C. Kao*. Nitric oxide induces prion protein via MEK and p38 MAPK signaling. Biochem. Biophys. Res. Commun. 2005;333: 95-100.
S.-L. Law*, T.-C. Chuang, M.-C. Kao, Y.-S. Lin, K.-J. Huang. Gene transfer mediated by sphingosine/ dioleoylphosphatidylethanolamine liposomes in the presence of poloxamer 188. Drug Deliv. 2006;3: 61-67.
T.-C. Chuang*, J.-Y. Liu, C.-T. Lin, Y.-T. Tang, M.-H. Yeh, S.-C. Chang, J.-W. Li, M.-C. Kao*. Human manganese superoxide dismutase suppresses HER2/neu-mediated breast cancer malignancy. FEBS Lett. 2007; 581: 4443-4449.
C.-C. Ou, S.-C. Hsu, Y.-H. Hsieh, W.-L. Tsou, T.-C. Chuang, J.-Y. Liu*, M.-C. Kao*. Downregulation of HER2 by RIG1 involves the PI3K/Akt pathway in ovarian cancer cells. Carcinogenesis. 2008;29: 299-306.
S.-C. Hsu, C.-C. Ou, J.-W. Li, T.-C. Chuang*, H.-P. Kuo, J.-Y, Liu, C.-S. Chen, S.-C. Lin, C.-H. Su, M.-C. Kao*. Ganoderma tsugae extracts inhibit colorectal cancer cell growth via G(2)/M cell cycle arrest. J. Ethnopharmacol. 2008; 120: 394-401.
J.-Y. Liu, T.-C. Chuang*, T.-D. Way, T.-C. Tsai, C.-L. Hu, G.-Y. Liu, S.-S.-Wang, J.-G. Chung, M.-C. Kao*. The N-terminal domain of EBNA1 acts as a suppressor of the HER2/neu oncogene. Cancer Lett. 2009; 273: 273-280.
V. Wang#, T.-C. Chuang#, B.-W. Soong, D.-E. Shan*, M.-C. Kao*. Octarepeat changes of prion protein in Parkinson’s disease. Parkinsonism Relat. Disord. 2009; 15: 53-58. (#co-first author)
S.-C. Hsu, C.-C. Ou, T.-C. Chuang*, J.-W. Li, Y.-J. Lee, V. Wang, J.-Y. Liu, C.-S. Chen, S.-C. Lin*, M.-C. Kao*. Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: in vitro and in vivo. Cancer Lett. 2009; 281: 108-116.
V. Wang*, S.-Y. Chen, T.-C. Chuang, D.-E Shan, B.-W. Soong, M.-C. Kao*. Val-9Ala and Ile+58Thr polymorphism of MnSOD in Parkinson’s disease. Clin. Biochem. 2010; 43: 979-982.
H.-P. Kuo, T.-C. Chuang, M.-H. Yeh, S.-C. Hsu, T.-D. Way, P.-Y. Chen, S.-S. Wang, Y.-H. Chang, M.-C. Kao*, J.-Y. Liu*. Growth suppression of HER2-overexpressing breast cancer cells by berberine via modulating the HER2/PI3K/Akt signaling pathway. J. Agric. Food Chem. 2011; 59: 8216-8224.
T.-C. Chuang*, S.-C. Hsu, Y.-T. Cheng, W.-S. Shao, K. Wu, G.-S. Fang, C.-C. Ou, V. Wang. Magnolol down-regulates HER2 gene expression, leading to inhibition of HER2-mediated metastatic potential in ovarian cancer cells. Cancer Lett. 2011; 311: 11-19.
V.-C. Wang*, J.-W. Li, J.-H. Suen, T.-C. Chuang, M.-C. Kao. Ile/Ile homozygosity at codon 655 of HER2 in schwannoma. Acta Neurol. Taiwan. 2011; 20: 243-248.
H.-P. Kuo, T.-C. Chuang, S.-C. Tsai, H.-H. Tseng, S.-C. Hsu, Y.-C. Chen, C.-L. Kuo, Y.-H. Kuo, J.-Y. Liu, M.-C. Kao*. Berberine, an Isoquinoline Alkaloid, Inhibits the Metastatic Potential of Breast Cancer Cells via Akt Pathway Modulation. J. Agric. Food Chem. 2012; 60: 9649-9658.
V. Wang*, T.-C. Chuang, M.-C. Kao, D.-E Shan, B.-W. Soong, T.-M. Shieh. Polymorphic Ala-allele carriers at residue 1170 of HER2 associated with Parkinson’s disease. J Neurol Sci. 2013; 325(1-2):115-9.
H.-P. Kuo, S.-C. Hsu, C.-C. Ou, J.-W. Li, H.-H. Tseng, T.-C. Chuang, J.-Y. Liu, S.-J. Chen, M.-H. Su, Y.-C. Cheng, W.-Y. Chou, M.-C. Kao*. Ganoderma tsugae extract inhibits growth of HER2-overexpressing cancer cells via modulation of HER2/PI3K/Akt signaling pathway. Evid Based Complement Alternat Med. 2013; 2013:219472.
H.-P. Kuo, Y.-J. Lee, C.-Y. Hsu, S.-L. Lee, S.-C. Hsu, T.-C. Chuang, J.-Y. Liu, C.-L. Kuo, C.-T. Ho, M.-C. Kao*. Growth-suppressive effect of berberine on endometrial carcinoma cells: Role of mitochondrial and PI3K/Akt pathway. J Funct Foods. 2015; 17: 600-609.
Chuang TC*, Wu K, Lin YY, Kuo HP, Kao MC, Wang V, Hsu SC, Lee SL. Dual down-regulation of EGFR and ErbB2 by berberine contributes to suppression of migration and invasion of human ovarian cancer cells. Environ Toxicol. 2021; 36(5):737-747.
Chuang TC*, Shao WS, Hsu SC, Lee SL, Kao MC, Wang V. Baicalein Induces G2/M Cell Cycle Arrest Associated with ROS Generation and CHK2 Activation in Highly Invasive Human Ovarian Cancer Cells. Molecules 2023; 28: 1039.