【光譜感測與先進材料實驗室】誠摯歡迎有志一同研究的同學加入本實驗室。
我們研究功能性奈米材料的合成、表面修飾、以及應用。在過程中，發展分析方法，以發掘「同質或異質奈米材料之間」或「奈米材料與分子之間」的交互作用模式，探討衍生其中的能量與結構變化，使外溢成為感測、生醫、能量、與催化等應用技術。
近年重點貢獻:
A. 利用「螢光碳點」控制「奈米銀顆粒」的聚集，使形成中空的複合角錐結構，並在這個半封閉空間中促成「表面增強拉曼」與「螢光」這兩個獨立光學現象的耦合 (coupling)。
B.在各式剛性或柔性載體上建構分子環境，以優化奈米材料、檢體、或光敏劑等的吸附，以形成光譜檢測基材 (substrate)、分子分離固相 (stationary phase)、催化劑、或光能轉換介質。
C. 利用獨特的介面技術，合成形態特殊的奈米金基材，實現在原生介質中定位、裁切雙硫鍵，以利辨識蛋白質的表面增強拉曼光譜能力。
D. 發展光譜數據存取與處理程式 (SQL/Python/C++)，另以類黃酮為模型，建立拉曼光譜統計分析方法，以構建傳統與表面增強拉曼光譜分析的「機器學習」平台。
E. 抗菌、類藥物 (drug-like)、與其它具生物活性「奈米碳點」的合成與應用。
F. 持續精進表面增强拉曼光譜量測的靈敏度，例如液相量測的靈敏度已達 10-18 M，用於食品染料偵測的固相感測器靈敏度則可達 10-15 M。
團隊成員:
光譜感測 (Molecular Sensing) – 王俊皓 (研究生)、林芷榆 (研究生)
應用材料 (Applied Materials) – 余浚希 (研究生)、連品源 (專題生)、林珈安 (專題生)
奈米材料 (Nano Materials) – 游晴伃 (專題生)、游曉汝 (專題生)、陳昱錡 (專題生)
永續材料 (Sustainable Materials) – 陳妍如 (專題生)
光譜資訊技術小組 – 王俊皓、游晴伃、陳昱錡
(團隊2024/07/03 於Lady M –)
進行中「國科會計畫」:
1. 113年度 專題研究計畫: 建立集捕捉、預濃縮、可視化、與光譜鑑定功能於一體的「微/奈米塑膠粒」分析平台。
2. 113年度 大專學生研究計畫: Spectroscopic exploration of the behavior for a liquid drop at the hydrophobic-hydrophilic interface。
歷年期刊著作:
1. Tsun Hei Yu, Pin-Yuan Lian, Jhih-Yu Lin, Li-Yu Chou, Yan Ru Chen, and Chia-Chi Huang*, “Improving Undergraduate Organic Chemistry Laboratories through Integration with Research: Prospects and a Model Study”, Journal of Chemical Education (2024) 101: 1642.
2. Matthew Heras, Chia-Chi Huang, Ching-Wen Chang*, Kuan-Hung Lu*, “Trends in chitosan-based films and coatings: A systematic review of the incorporated biopreservatives, biological properties, and nanotechnology applications in meat preservation”, Food Packaging and Shelf Life (2024) 42: 101259.
3. Wei-Lun Huang, Chia-Jung Hsu, Jun Hao Wang, Zi-Han Hsu, Kuan-Hung Lu, Wen-Der Wang, Chia-Chi Huang*, “Low-Toxicity Antibacterial Carbon Nanodots for Wound Dressings and Food Packaging”, ACS Applied Nano Materials (2023) 6: 19200.
4. Yi-Shan Hung, Chia-Wen Chang, Yi Chen Shen , Yun-Chi Yu, Wei-Lun Huang, Chia-Chi Huang*, “Spectroscopic Analyses of Particle and Energy Aggregations at the Interface of Silver Nanoparticles and Fluorescent Carbon Nanodots”, Nanoscale (2023) 15: 13987. (本篇文章獲選為當期Inside Back Cover).
5. Zi-Han Hsu, Li Hsu, Chia-Chi Huang*, “Polyacrylamide Gel Scaffold Immobilized with Silver Nanoparticles as SERS Substrates and Catalysts for H2 Generation via Methanolysis of NaBH4”, ACS Applied Nano Materials (2022) 5:2258.
6. Yu-San Chien, Chia-Wen Chang, Chia-Chi Huang*, “Differential Surface Partitioning for An Ultrasensitive Solid-State SERS Sensor and Its Application to Food Colorant Analysis”, Food Chemistry (2022) 383:132415.
7. Chia-Chi Huang*, Zi-Han Hsu, Yen-Shi Lai, “Raman Spectroscopy for Virus Detection and The Implementation of Unorthodox Food Safety”, Trends in Food Science & Technology (2021) 116:525.
8. Chia-Chi Huang*, Yen-Shi Lai, Chih-Hsien Wang, Lai-Kwan Chau, Wenlung Chen*, “Label-Free SERS Characterization of Snake Venoms by Exploring the Cysteine Environs with Bone-Shaped Gold Nanoparticles”, Journal of Materials Chemistry B (2020) 8:10744. (本篇文章獲選為當期 Back Cover).
9. Chia-Chi Huang*, Chi-Yun Cheng, Yen-Shi Lai, “Paper-Based Flexible Surface Enhanced Raman Scattering Platforms and Their Applications to Food Safety”, Trends in Food Science & Technology (2020) 100:349.
10. Chia-Chi Huang*, “Unusual Diets in A Pandemic Crisis,” Journal of Dietetics and Food Technology (2020) 1: 005.
11. Chih-Hsien Wang, Chia-Chi Huang*, Wenlung Chen*, and Yen-Shi Lai, “The Chemical Aspects of Raman Spectroscopy: Statistical Structure-Spectrum Relationship in The Analyses of Flavonoids”, Journal of Food and Drug Analysis (2020) 28:45.
12. Chia-Chi Huang*, Yi-Shan Hung, Yih-Ming Weng, Wenlung Chen, Yen-Shi Lai, “Sustainable Development of Carbon Nanodots Technology: Natural Products as A Carbon Source and Applications to Food Safety”, Trends in Food Science & Technology (2019) 86:144.
13. Chia-Chi Huang*, Chi-Yun Cheng, Chao-Ting Chou and Wenlung Chen*, “Adsorbate Enrichment on Zeolite Surface and Assembly of A SERS Sensor: A Case Study with Silver Nanoparticles and The Flavonoid Catechin”, RSC Advances (2019) 9:1048, IF: 4.036.
14. Chia-Chi Huang*, Wenlung Chen*, “A SERS method with attomolar sensitivity: a case study with the flavonoid catechin”, Microchimica Acta (2018) 185: 120.
15. Chia-Chi Huang*, Wenlung Chen*, “Raman Spectroscopic Analysis of Cataract Lens: A Compendious Review”, Applied Spectroscopy Reviews (2018) 53: 689.
16. Cheng-Liang Huang, Chia-Chi Huang*, Wenlung Chen*, “A Report from the 5th International Taiwan Symposium on Raman Spectroscopy (TISRS 2017) and Taiwan Association of Raman Spectroscopy (TARS) Summer Camp”, Journal of Raman Spectroscopy (2018) 49: 594.
17. Chih-Hsien Wang, Chia-Chi Huang, and Wenlung Chen*, “Simultaneous Separation of Txon-Specific Crystallins from Mule Duck and Characterization of Their Enzymatic Activities and Structures”, Journal of Chromatography B (2017) 1053: 34.
18. Chia-Chi Huang*, Ciro Isidoro**, “Raman Spectrometric Detection Methods for Early and Non-Invasive Diagnosis of Alzheimer’s Disease”, Journal of Alzheimer’s Disease (2017) 57: 1145.
19. Chih-Wei Hsu, Chia-Chi Huang, Jeng-Horng Sheu, Chia-Wen Lin, Lien-Fu Lin, Jong-Shiaw Jin, Lai-Kwan Chau, Wenlung Chen*, “Novel Method for Differentiating Histological Types of Gastric Adenocarcinoma by Using Confocal Raman Microspectroscopy”, PLoS ONE (2016) 11: e0159829.
20. Chih-Wei Hsu, Chia-Chi Huang, Jeng-Horng Sheu, Chia-Wen Lin, Lien-Fu Lin, Jong-Shiaw Jin, Wenlung Chen*, “Differentiating Gastrointestinal Stromal Tumors from Gastric Adenocarcinomas and Normal Mucosae Using Confocal Raman Microspectroscopy”, Journal of Biomedical Optics (2016) 21: 075006.
21. Chih-Hsien Wang, Chia-Chi Huang, Long-Liu Lin and Wenlung Chen*, “The Effected of Disulfide Bonds on Protein Folding, Unfolding, and Misfolding Investigated by FT-Raman Spectroscopy”, Journal of Raman Spectroscopy (2016) 49: 594.
22. Lien-Fu Lin, Jong-Shiaw Jin, Jui-Chang Chen, Chia-Chi Huang, Jeng-Horng Sheu, Wenlung Chen, Tang Yi Tsao, Chih-Wei Hsu*, “Positive Cyclin T expression as a Favorable Prognostic Factor in Treating Gastric Gastrointestinal Stromal Tumors”, Molecular and Clinical Oncology (2016) 4: 971.
23. Chia-Chi Huang*, “Applications of Raman Spectroscopy in Herbal Medicine”, Applied Spectroscopy Reviews (2016) 51: 1.
24. Ciro Isidoro*, Chia-Chi Huang, Lee-Yan Sheen*, “Publishing Scientifically Sound Papers in Traditional and Complementary Medicine”, Journal of Traditional and Complementary Medicine, 6 (2016) 1-4.
25. Ciro Isidoro*, Chia-Chi Huang, Lee-Yan Sheen*, “Report from the Second International Conference of Traditional and Complementary Medicine on Health 2015”, Journal of Traditional and Complementary Medicine, 6 (2016) 5-9.
26. Jong-Shiaw Jin, Lien-Fu Lin, Jui-Chang Chen, Chia-Chi Huang, Jeng-Horng Sheu, Wenlung Chen, Tang-Yi Tsao, Chih-Wei Hsu*, “Increased Cyclin T1 Expression as a Favorable Prognostic Factor in Treating Gastric Adenocarcinoma”, Oncology Letters (2015) 10: 3712.
27. Chia-Chi Huang, Chen-Han Huang, I-Ting Kuo, Lai-Kwan Chau*, Tzzy-Schiuan Yang*, “Synthesis of Silica-coated Gold Nanorod as Raman Tags by Modulating Cetyltrimethylammonium Bromide Concentration”, Colloids and Surfaces A (2012) 409: 61.
28. Hsing-Ying Lin, Chen-Han Huang, Chia-Chi Huang, Yu-Chia Liu, and Lai-Kwan Chau*, “Multiple Resonance Fiber-Optic Sensor with Time Division Multiplexing for Multianalyte Detection”, Optics Letters (2012) 37: 3969.
29. Le Dac Tuyen, An Chi Liu, Chia-Chi Huang, Pei-Cheng Tsai, Jian Hung Lin, Chin-Wei Wu, Lai-Kwan Chau*, Tzyy Schiuan Yang, Le Quoc Minh, Hung-Chih Kan*, and Chia Chen Hsu*, “Doubly Resonant Surface-Enhanced Raman Scattering on Gold Nanorod Decorated Inverse Opal Photonic Crystals”, Optics Express (2012) 20: 29266.
30. Cheng Yi Wu, Chia Chi Huang, Jia Sin Jhang, An Chi Liu, Chun-Chen Chiang, Ming-Lung Hsieh, Ping-Ji Huang, Le Dac Tuyen, Le Quoc Minh, Tzyy-Schiuan Yang, Lai-Kwan Chau, Hung-Chih Kan*, and Chia Chen Hsu*, “Hybrid Surface-Enhanced Raman Scattering Substrate from Gold Nanoparticle and Photonic Crystal: Maneuverability and Uniformity of Raman Spectra”, Optics Express (2009) 20: 29266.
研討會論文:
國際研討會 – Invited Speech:
1. “The detection of food colorants by an ultrasensitive solid-state SERS sensor”, Taiwan International Symposium on Raman Spectroscopy and Taiwan Association of Raman Spectroscopy, Japan, 2022.
2. “A Rapid and Sensitive SERS Detection of Catechin in Green Tea Beverages,” The 6th Taiwan International Symposium on Raman Spectroscopy (TISRS 2018) and Taiwan Association of Raman Spectroscopy, Japan, 2018.
3. “Ultrasensitive SERS detection of catechin in solution,” The 5th International Congress on Microscopy and Spectroscopy, Turkey, 2018.
4. “A simple and effective way to fabricate a silica-coated gold nanorod as a Raman-fluorescence dual tag,” The 1st Taiwan International Symposium on Raman Spectroscopy, Taiwan, 2013.
國際研討會 – Oral Presentation:
1. “A Novel Confocal Raman Microspectroscopic Method for Recognizing Gastric Adenocarcinoma and Gastrointestinal Stromal Tumors”, The 26th International Conference on Raman Spectroscopy (ICORS 2018), Korea, 2018.
國內研討會/會議 – Invited Speech:
1. “The biological and spectroscopic applications of carbon nanodots”, 化學年會，淡江大學，2024。
2. “Applications of Optically and Morphologically Distinctive Carbon Nanodots”, 第二十九屆分析技術交流研討會，臺灣師範大學，2024。
3. “Label-Free SERS Sensing of Snake Venoms”, 第二十六屆分析技術交流研討會，輔仁大學，2021。
4. “表面增強拉曼散射光譜與共軛焦顯微拉曼光譜技術之檢測應用”, 分析小組春季會議，高雄醫學大學，2019。
5. “食品安全容器與健康 – 淺談美耐皿”, 財團法人塑膠工業技術發展中心，2017。
6. “學術期刊編輯之工作經驗分享”, 南華大學，2017。
7. “國際科學期刊投審稿流程與工作經驗分享”, 中正大學，2014。