{"id":3776,"date":"2024-05-01T15:34:19","date_gmt":"2024-05-01T07:34:19","guid":{"rendered":"\/chemistry\/?p=3776"},"modified":"2026-09-17T11:45:29","modified_gmt":"2026-09-17T03:45:29","slug":"%e9%99%b3%e6%9b%9c%e9%b4%bb","status":"publish","type":"post","link":"\/chemistry\/?p=3776","title":{"rendered":"\u9673\u66dc\u9d3b(\u671f\u520a,\u6d3b\u52d5\u7167\u7247)"},"content":{"rendered":"\n<div class=\"wp-block-tkuwpbs5-bs5-container container chem_teach\" style=\"margin-top:var(--wp--preset--spacing--40);padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50);position:relative\" block_id=\"lq3fs6oyzthhmnpj8a\"><style><\/style>\n<div class=\"wp-block-tkuwpbs5-bs5-row row\">\n<h4 class=\"wp-block-heading\"><strong>\u7814\u7a76\u5167\u5bb9\u7c21\u4ecb<\/strong><\/h4>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>\u57fa\u5e95\u7d30\u80de\u764c(basal cell carcinoma)<\/strong><\/h5>\n\n\n\n<p><strong>\u57fa\u5e95\u7d30\u80de\u764c\u662f\u6700\u5e38\u898b\u7684\u76ae\u819a\u764c<\/strong>\uff0c\u5927\u7d04\u4f54\u6240\u6709\u76ae\u819a\u60e1\u6027\u816b\u7624\u768480%\u4ee5\u4e0a\uff0c\u597d\u767c\u65bc\u982d\u81c9\u3001\u9838\u548c\u624b\u90e8\u3002\u9019\u7a2e\u764c\u75c7\u751f\u9577\u7de9\u6162\u800c\u901a\u5e38\u4e0d\u6703\u8f49\u79fb\u5230\u5176\u4ed6\u90e8\u4f4d\uff0c<strong>\u4f46\u662f\u82e5\u6c92\u6709\u8655\u7f6e\uff0c\u6703\u5c40\u90e8\u7834\u58de\u53ca\u4fb5\u72af\u7d44\u7e54\uff0c\u4f8b\u5982\u9aa8\u982d\u53ca\u795e\u7d93<\/strong>\u3002\u5728\u57fa\u56e0\u5c64\u6b21\u65b9\u9762\u7684\u7814\u7a76\uff0c\u57fa\u5e95\u7d30\u80de\u764c\u5176\u4e3b\u8981\u6210\u56e0\u70ba<em>sonic hedgehog&nbsp;<\/em><em>(shh)<\/em>\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u904e\u5ea6\u6d3b\u5316\u6240\u5c0e\u81f4\u7684\u764c\u75c7\u3002\u5728\u52d5\u7269\u6a21\u5f0f\u7684\u5be6\u9a57\u4e2d\uff0c\u4ee5\u5c0f\u9f20\u7684\u7814\u7a76\u70ba\u4f8b\uff0cOro\u7b49\u4eba(1997)\u5c07\u88abkeratin\u555f\u52d5\u5b50\u6240\u9a45\u52d5\u7684<em>shh<\/em>\u57fa\u56e0\u5229\u7528\u57fa\u56e0\u8f49\u6b96\u7684\u6280\u8853\uff0c\u8b93<em>shh<\/em>\u57fa\u56e0\u5c08\u4e00\u6027\u5730\u5728\u8868\u76ae\u7d44\u7e54\u904e\u5ea6\u8868\u73fe\uff0c\u7d50\u679c\u9019\u4e9b\u57fa\u56e0\u8f49\u6b96\u5c0f\u9f20\uff0c\u5448\u73fe\u51fa\u591a\u8dbe(polydactyly)\u3001\u810a\u67f1\u88c2\u958b(spina 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rerio<\/em>)\u662f\u4e00\u7a2e\u5c0f\u578b\u89c0\u8cde\u9b5a\uff0c\u6210\u9b5a\u9ad4\u9577\u7d043\u516c\u5206\uff0c\u597d\u990a\u53c8\u4fbf\u5b9c\uff0c\u9ad4\u7a4d\u5c0f\uff0c\u4e00\u822c\u7684\u5bb6\u7528\u4e00\u5c3a\u6c34\u65cf\u7bb1\u5927\u7d04\u53ef\u990a20\u96bb\u5de6\u53f3\uff0c\u53ef\u5927\u5927\u5730\u964d\u4f4e\u990a\u6b96\u6210\u672c\u3002\u9019\u985e\u5c0f\u578b\u9b5a\u7a2e\u64c1\u6709\u5375\u7684\u6578\u91cf\u591a(\u6bcf\u9031\u53ef\u7522100-300\u9846\u5375)\uff0c\u5375\u5f91\u5927\u800c\u4e14\u900f\u660e\uff0c\u6c92\u6709\u7522\u5375\u671f\u7684\u9650\u5236\uff0c\u9ad4\u5916\u6388\u7cbe\uff0c\u6574\u500b\u80da\u80ce\u767c\u80b2\u53ca\u5668\u5b98\u5f62\u6210\u7684\u904e\u7a0b\u90fd\u53ef\u4ee5\u76f4\u63a5\u5728\u986f\u5fae\u93e1\u4e0b\u89c0\u5bdf\uff0c\u57fa\u56e0\u8f49\u6b96\u64cd\u4f5c\u7c21\u55ae\u3001\u6210\u719f\u671f\u53c8\u53ea\u67092-3\u500b\u6708\u7b49\u512a\u9ede\u3002\u56e0\u6b64\uff0c\u6591\u99ac\u9b5a\u5df2\u6210\u70ba\u7814\u7a76\u764c\u75c7\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u5668\u5b98\u767c\u80b2\u3001\u810a\u690e\u52d5\u7269\u80da\u80ce\u767c\u80b2\u3001\u795e\u7d93\u767c\u80b2\u3001\u7d30\u80de\u51cb\u4ea1\u7684\u91cd\u8981\u6a21\u5f0f\uff0c\u5728\u85e5\u7269\u6bd2\u6027\u7684\u7be9\u6aa2\u4e5f\u626e\u6f14\u91cd\u8981\u89d2\u8272\u3002\u6591\u99ac\u9b5a\u5728\u6297\u764c\u85e5\u7269\u7684\u7be9\u9078\u4e0a\u6700\u5927\u7684\u597d\u8655\u662f\u751f\u9577\u9031\u671f\u77ed\uff0c\u53ef\u4ee5\u5f88\u5feb\u901f\u3001\u5f88\u6709\u6548\u7387\u7684\u8a55\u4f30\u7642\u6548\uff0c\u4e26\u4e14\u98fc\u990a\u6210\u672c\u53ea\u6709\u5c0f\u767d\u9f20\u7684\u767e\u5206\u4e4b\u4e00\u81f3\u5343\u5206\u4e4b\u4e00\uff0c\u975e\u5e38\u9069\u5408\u85e5\u7269\u7684\u7be9\u9078\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-row row\">\n<div class=\"wp-block-tkuwpbs5-bs5-column col-md-12 align-self-start\"><img decoding=\"async\" src=\"\/chemistry\/wp-content\/uploads\/2024\/05\/cmlsboneToxicolSci.jpg\" class=\"img-fluid img-fluid \" alt=\"\u4e0a\u50b3\u5716\u7247\"><\/div>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-row row\">\n<h4 class=\"wp-block-heading\"><strong>\u5c08\u696d\u670d\u52d9<\/strong><\/h4>\n\n\n\n<p>(1) <strong>\u570b\u969b\u671f\u520a\u5be9\u7a3f\u59d4\u54e1<\/strong><strong>(Reviewer):&nbsp;<\/strong>Journal of Fish Biology, Photochemistry and Photobiology, Food and Chemical Toxicology, Environmental Toxicology, Journal of Peptide Science, Expert Opinion on Drug Discovery<\/p>\n\n\n\n<p>(2) <strong>\u570b\u969b\u671f\u520a\u7de8\u5be9\u59d4\u54e1<\/strong><strong>(<\/strong><strong>Editorial Board Member<\/strong><strong>):&nbsp;<\/strong>Biotechnology Research International, International Journal of BiotechScience<\/p>\n\n\n\n<p>(3) <strong>\u570b\u969b\u671f\u520a\u526f\u4e3b\u7de8<\/strong><strong>(<\/strong><strong>Associate Editor<\/strong><strong>):&nbsp;<\/strong>International Journal of Biotechnology Applications<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-row row\">\n<h4 class=\"wp-block-heading\"><strong>\u5c08\u5229<\/strong><\/h4>\n\n\n\n<p>\u5375\u9ec3\u6cb9\u812b\u8272\u812b\u5473\u4e4b\u88fd\u5099\u65b9\u6cd5(\u4e2d\u83ef\u6c11\u570b\u5c08\u5229\uff0c\u767c\u660e\u7b2cI741469\u865f\uff0c\u5df2\u9818\u8b49\uff0c\u7f8e\u570b\u5c08\u5229\u9818\u8b49\u4e2d)<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-row row\">\n<h4 class=\"wp-block-heading\"><strong>\u8fd1\u5e74\u8457\u4f5c\u76ee\u9304<\/strong><\/h4>\n\n\n\n<p>(1) <strong><em>Chen YH*,<\/em><\/strong><em> Mohanty B, Li TS, et al. (2026).<\/em> A phenotype-driven discovery of pro-revascularization chalcone derivatives using zebrafish and CAM models. <em>Journal of Toxicology<\/em>, 2026: 6939974.<\/p>\n\n\n\n<p>(2) <em>Lee ASY, Lin TH, Liu YY, et al.,<\/em><strong><em> Chen YH*<\/em><\/strong><em> (2025). <\/em>Growth inhibition and toxicity assessments of cis-3,4-diaryl-\u03b1-methylene-\u03b3-butyrolactams in cultured human renal cancer cells and zebrafish embryos. <em>Biochimica et Biophysica Acta-General Subjects<\/em>, 1869:130761.\u00a0<\/p>\n\n\n\n<p>(3) Zhang HW, Tsai ZR, Kok VC*, Peng HC,<strong>\u00a0Chen YH,<\/strong>\u00a0Tsai JJP, Hsu, CY (2022) Long-term ambient hydrocarbon exposure and incidence of urinary bladder cancer.\u00a0<em>Scientific Reports<\/em>\u00a012: 20799.<\/p>\n\n\n\n<p>(4) Pan HC<sup>#<\/sup>,\u00a0<strong>Chen YH<sup>#<\/sup><\/strong>, Fang WC, Wu VC, Sun CY* (2022)\u00a0Essential roles of the histone demethylase KDM4C in renal development\u00a0and acute kidney injury.\u00a0<em>International Journal of Molecular Sciences<\/em>\u00a023: 9318.<\/p>\n\n\n\n<p>(5) Lu PH, Liao TH,\u00a0<strong>Chen YH<\/strong>, Hsu YL, Kuo CY, Chan CC, Wang LK, Chern CY*, Tsai FM* (2022)\u00a0Coumarin derivatives inhibit ADP-induced platelet activation and aggregation.\u00a0<em>Molecules<\/em>27: 4054.<\/p>\n\n\n\n<p>(6) Liu CF, Ou Yang Y, Huang CY, Jao SW, Kuo YK, Chen HC, Cheng SC, Wang NK, Chuang LH,\u00a0<strong>Chen YH*<\/strong>, Chen WY* (2022) Zebrafish (<em>Danio rerio<\/em>) is an economical and efficient animal model for screening potential anti-cataract compounds.\u00a0<em>Translational Vision Science &amp; Technology<\/em>\u00a011: 21.<\/p>\n\n\n\n<p>(7) Kuo YK, Chen YT, Chen HM, Wu PC, Sun CC, Yeung L, Lin KK, Chen HC, Chuang LH, Lai CC,\u00a0<strong>Chen YH<\/strong>, Liu CF* (2022) Efficacy of myopia control and distribution of corneal epithelial thickness in children treated with orthokeratology assessed using optical coherence tomography.\u00a0<em>Journal of Personalized Medicine<\/em>\u00a012: 278.<\/p>\n\n\n\n<p>(8) Tang PWH, Wu PH, Lin YT, Chiu CH, Cheng TL, Guan WH, Lin HYH, Lee KT,\u00a0<strong>Chen YH<\/strong>, Liu W* (2022) Zebrafish model-based assessment of Indoxyl sulfate-induced oxidative stress and its impact\u00a0on renal and cardiac development.\u00a0<em>Antioxidants<\/em>\u00a011: 400.<\/p>\n\n\n\n<p>(9) Sun CY, Chang SC, Wang HP, Lee YJ, Pan KH, Lin CL, Hsieh YT, Ta YC,\u00a0<strong>Chen YH<\/strong>, Chang MF* (2021) LMBD1 protein participates in cell mitosis by regulating microtubule assembly.\u00a0<em>Biochemical Journal<\/em>\u00a0478: 2321-2337.<\/p>\n\n\n\n<p>(10) Tsai JN, Ding YJ<strong>,<\/strong>\u00a0Lo KC,\u00a0Lu PH, Chang CF, Wen CC, Wang BC*,Yang LL*,\u00a0<strong>Chen YH*<\/strong>\u00a0(2021) Protective role of Bu-Zhong-Yi-Qi decoction\u00a0on\u00a0aristolochic acid-intoxicated zebrafish.\u00a0<em>Tropical Journal of Pharmaceutical Research<\/em>\u00a020: 605-611.<\/p>\n\n\n\n<p>(11) Hsieh KH, Hsu CY, Hung IJ, Yeh CL,\u00a0<strong>Chen YH<\/strong>, Cheng CC*(2021) Positively charged liposomes consisting of the KTTKS pentapeptide conjugated with rhodamine increase rhodamine toxicity in<em>\u00a0E. coli\u00a0<\/em>and zebrafish embryo.\u00a0<em>Journal of the Chinese Chemical Society<\/em>\u00a068: 34-38.<\/p>\n\n\n\n<p>(12) Lu PL, Lee HY, Liou YL, Tung SF, Kuo KL,\u00a0<strong>Chen YH*<\/strong>\u00a0(2020)\u00a0Nephroprotective role of Zhibai Dihuang Wan in aristolochic acid intoxicated zebrafish.\u00a0<em>BioMed Research International<\/em>\u00a0Article ID 5204384.<\/p>\n\n\n\n<p>(13) Wang YH*,\u00a0<strong>Chen YH<\/strong>, Shen WH (2020)\u00a0Amikacin suppresses human breast cancer cell MDA-MB-231 migration and invasion.\u00a0<em>Toxics<\/em>\u00a08: 108.<\/p>\n\n\n\n<p>(14) Sun CY, Chou CY, Hsieh YT, Lo KC, Liou YL,\u00a0<strong>Chen YH*<\/strong>\u00a0(2020)\u2002Klotho exerts an emerging role in cytokinesis.\u00a0<em>Genes<\/em>\u00a011: 1048.<\/p>\n\n\n\n<p>(15) <strong>Chen YH*<\/strong>, Chen YJ, Chou CY, Wen CC, Cheng CC* (2019) UV-protective activities of pineapple leaf extract in zebrafish embryos.\u00a0<em>Research on Chemical Intermediates<\/em>\u00a045: 65-75.<\/p>\n\n\n\n<p>(16) <strong>Chen YH<\/strong>, Tai HY, Fu E, Don TM* (2019) Guided bone regeneration activity of different calcium phosphate\/chitosan hybrid membrane.\u00a0<em>International Journal of Biological Macromolecules<\/em>\u00a0126: 159-169.<\/p>\n\n\n\n<p>(17) Hsieh CS, Tsai CT,\u00a0<strong>Chen YH<\/strong>, Chang SN, Hwang JJ, Chuang EY*,\u00a0Wu\u00a0IH* (2018)\u00a0Global expression profiling identifies a novel\u00a0hyaluronan synthases 2 gene\u00a0in the pathogenesis of lower extremity varicose veins.\u00a0<em>Journal of Clinical Medicine<\/em>\u00a07: 537.<\/p>\n\n\n\n<p>(18) Tsai JN, Sun CY, Ding YJ, Wang YH, Lo KC, Weng CC, Lin JW, Chang CF, Hsu LS, Chen HM, Fong TH*,\u00a0<strong>Chen YH*<\/strong>\u00a0(2018) Embryonic exposure to 4-methylimidazole leads to zebrafish myofibril misalignment.\u00a0<em>Environmental Toxicology<\/em>\u00a033: 1321-1328.<\/p>\n\n\n\n<p>(19) Sun CY*, Wu MS, Lee CC, Chen SH, Lo KC,\u00a0<strong>Chen YH*<\/strong>\u00a0(2018) A novel SNP in the 5\u2019 regulatory region of organic anion transporter 1 is associated with chronic kidney disease.\u00a0<em>Scientific Reports<\/em>\u00a08: 8085.<\/p>\n\n\n\n<p>(20) Chu HF, Chen CC, Moses DC,\u00a0<strong>Chen YH<\/strong>, Lin CH, Tsai YC, Chou CY (2018) Porcine epidemic diarrhea virus papain-like protease 2 can be noncompetitively\u00a0inhibited by 6-thioguanine.\u00a0<em>Antiviral Research<\/em>\u00a0158: 199-205.<\/p>\n\n\n\n<p>(21) Lin MH, Moses DC, Cheng SC,\u00a0<strong>Chen YH<\/strong>, SunCY*, Chou CY* (2018) Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes.<em>Antiviral Research<\/em>\u00a0150: 155-163.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-row row\">\n<h4 class=\"wp-block-heading\"><strong>\u6d3b\u52d5\u82b1\u7d6e<\/strong><\/h4>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-column col-md-12 align-self-start\"><img decoding=\"async\" src=\"\/chemistry\/wp-content\/uploads\/2024\/05\/003-22yau-hung4.jpg\" class=\"img-fluid img-fluid \" alt=\"\u4e0a\u50b3\u5716\u7247\"><\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":22,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"wp-custom-template-member-empty-template","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"acf":[],"_links":{"self":[{"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/posts\/3776"}],"collection":[{"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/users\/22"}],"replies":[{"embeddable":true,"href":"\/chemistry\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3776"}],"version-history":[{"count":10,"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/posts\/3776\/revisions"}],"predecessor-version":[{"id":10008,"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/posts\/3776\/revisions\/10008"}],"wp:attachment":[{"href":"\/chemistry\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3776"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/chemistry\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3776"},{"taxonomy":"post_tag","embeddable":true,"href":"\/chemistry\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3776"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}